Investigating how a specific protein affects liver disease related to alcohol consumption
Role of phospho UBC9 in alcohol-associated liver disease
This study is looking at how a protein called phospho UBC9 affects liver problems caused by drinking too much alcohol, and it aims to find out how alcohol triggers liver inflammation and damage, which could help us understand and treat alcoholic liver disease better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10897936 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called phospho UBC9 in the development of alcoholic liver disease (ALD), which is caused by chronic alcohol consumption. The study examines how alcohol leads to liver inflammation and injury by activating certain immune cells in the liver. Researchers will explore the mechanisms by which UBC9 is modified and how this affects liver cell function and inflammation. By analyzing these processes, the research aims to uncover new insights into the biological pathways involved in ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who are experiencing liver-related health issues.
Not a fit: Patients who do not consume alcohol or have liver disease due to non-alcoholic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of liver disease related to alcohol, but the specific role of phospho UBC9 is still being explored.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Tomasi, Maria Lauda — Cedars-Sinai Medical Center
- Study coordinator: Tomasi, Maria Lauda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.