Investigating how a specific protein affects liver disease caused by alcohol consumption
FKBP5 in the pathogenesis of alcohol-associated liver disease
This study is looking at how a protein called FKBP51 affects liver damage caused by drinking alcohol, and it aims to find new ways to help people with alcohol-related liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10871702 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of FKBP51, a protein linked to cellular signaling, in the development of alcohol-associated liver disease (ALD). Researchers will explore how alcohol consumption influences the expression of FKBP5 in the liver, particularly looking at changes in its genetic regulation. By studying both human liver samples and animal models, the project aims to uncover the mechanisms by which FKBP5 contributes to liver injury from alcohol. This could lead to new insights into potential therapeutic targets for patients suffering from ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease, particularly those with alcoholic cirrhosis.
Not a fit: Patients who do not consume alcohol or have liver disease from non-alcoholic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent alcohol-associated liver disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of FKBP5 in other conditions, suggesting that this approach may yield valuable insights for alcohol-associated liver disease.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Liangpunsakul, Suthat — Indiana University Indianapolis
- Study coordinator: Liangpunsakul, Suthat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.