Investigating how a specific protein affects liver disease caused by alcohol
The role of PDK4 in alcohol-associated liver disease
This study is looking at how a protein called PDK4 affects liver health in people with alcohol-related liver disease, hoping to find new ways to help those who are struggling with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10914149 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called PDK4 in alcohol-associated liver disease (ALD). It aims to uncover how PDK4 influences mitochondrial function and inflammation in the liver when exposed to alcohol. By studying the molecular mechanisms involved, the research seeks to identify potential new treatment options for patients suffering from ALD. The approach includes examining cellular responses to alcohol and how PDK4 may affect liver health and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease.
Not a fit: Patients with liver disease not related to alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating alcohol-associated liver disease.
How similar studies have performed: Other research has shown promise in understanding the molecular mechanisms of liver diseases, but the specific role of PDK4 in alcohol-associated liver disease is still being explored.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Wu, Jianguo — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Wu, Jianguo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.