Investigating how a specific protein affects lipid metabolism in the brain and its role in aging and neurodegeneration.
Role of TTYH1 in mobilizing lipids and ApoE in glia: Implications for brain aging and neurodegeneration
This study is looking at how a protein called TTYH1 affects fat processing in brain cells, especially as we age and in conditions like Alzheimer's, to help us understand what might go wrong in brain cell function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project ID | NIH-11076644 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the TTYH1 protein in lipid metabolism within brain cells, particularly in relation to aging and neurodegenerative diseases like Alzheimer's. By examining how TTYH1 interacts with another protein, ApoE, and its impact on lipid processing in glial cells, the study aims to uncover the molecular pathways that may contribute to brain cell dysfunction. The researchers will use advanced techniques, including molecular genetics and lipidomic analyses, to explore these mechanisms in both human cells and model organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease or those experiencing early symptoms of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological processes underlying Alzheimer's disease, potentially paving the way for innovative treatments.
How similar studies have performed: While the specific focus on TTYH1 is novel, previous research has shown that lipid metabolism plays a crucial role in neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
Newark, United States
- Rutgers the State Univ of Nj Newark — Newark, United States (Active)
Researchers
- Principal investigator: Wong, Ching-on — Rutgers the State Univ of Nj Newark
- Study coordinator: Wong, Ching-on
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.