Investigating how a specific protein affects kidney damage from obesity
Official title: Role of Atp6ap2 in renal proximal tubule lipotoxicity
Funded at University of Virginia · NIH-11012906 · Data updated 2026-11-12
This study is looking at how a protein called ATP6AP2 affects kidney cells and their damage from obesity, hoping to find new ways to help people with kidney problems related to being overweight.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $165,240 |
| NIH project number | 5K08DK132463-03 |
| Project ID | NIH-11012906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity-related chronic kidney disease.
✕Less likely to help
Patients with kidney disease not related to obesity may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called ATP6AP2 in kidney cells, particularly how it contributes to kidney damage caused by obesity. The study examines how toxic lipids accumulate in kidney cells and how this process is influenced by obesity-related factors. By using animal models, the research aims to uncover the mechanisms behind these changes and identify potential new treatment strategies for obesity-related kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better protect the kidneys from damage caused by obesity.
How similar studies have gone: Other research has shown promising results in understanding kidney damage mechanisms related to obesity, but this specific approach is relatively novel.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Culver, Silas a — University of Virginia
- Study coordinator: Culver, Silas a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.