Investigating how a specific protein affects influenza virus infection
Official title: The Role of E3 Ligase MARCH10 in Influenza Virus Infection
Funded at Ohio State University · NIH-11002303 · Data updated 2026-11-12
This study is looking at a protein called MARCH10 to see how it affects lung cells during influenza infections, with the goal of finding new ways to boost the immune response and improve treatments for people with the flu.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $165,024 |
| NIH project number | 5K08HL171895-02 |
| Project ID | NIH-11002303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals who are at high risk for severe influenza infections, such as those with pre-existing lung conditions or weakened immune systems.
✕Less likely to help
Patients who are not affected by influenza or those who do not have any respiratory conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called MARCH10 in the context of influenza virus infections, which can lead to severe lung injuries. The study aims to explore how influenza virus infection affects the levels of MARCH10 in lung cells and how manipulating this protein could potentially enhance the body's immune response against the virus. By examining the molecular mechanisms involved, the researchers hope to identify new therapeutic targets that could improve treatment options for influenza patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that enhance the immune response to influenza, potentially reducing the severity of infections.
How similar studies have gone: While the specific role of MARCH10 in influenza has not been extensively studied, similar approaches targeting molecular regulators of viral infections have shown promise in other contexts.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Tsai, Muchun — Ohio State University
- Study coordinator: Tsai, Muchun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.