Investigating how a specific protein affects inflammation in COPD
Role of FABP5 in COPD Exacerbations
['FUNDING_R01'] · NATIONAL JEWISH HEALTH · NIH-10982119
This study is looking at how a protein called FABP5 affects inflammation in people with COPD, aiming to find new ways to help manage their symptoms and improve their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NATIONAL JEWISH HEALTH (nih funded) |
| Locations | 1 site (DENVER, UNITED STATES) |
| Trial ID | NIH-10982119 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of fatty acid binding protein 5 (FABP5) in regulating inflammation in chronic obstructive pulmonary disease (COPD). It aims to explore how FABP5 influences the behavior of lung macrophages, which are crucial for managing inflammation and preventing disease exacerbations. The study will investigate the genetic variations associated with FABP5 and their potential as therapeutic targets to improve patient outcomes. By examining the mechanisms of inflammation resolution, the research seeks to provide insights that could lead to new treatment strategies for COPD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD), particularly those experiencing frequent exacerbations.
Not a fit: Patients with mild or intermittent respiratory issues who do not have a diagnosis of COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help manage inflammation and reduce exacerbations in COPD patients.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory pathways in chronic lung diseases, indicating that this approach may yield beneficial outcomes.
Where this research is happening
DENVER, UNITED STATES
- NATIONAL JEWISH HEALTH — DENVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALLY, FABIENNE — NATIONAL JEWISH HEALTH
- Study coordinator: GALLY, FABIENNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Airway infections