Investigating how a specific protein affects inflammation in Alzheimer's disease
Microglial function of GWAS risk factor BIN1 in Alzheimer's disease pathogenesis and inflammatory signaling
This study is looking at a protein called BIN1 that is connected to Alzheimer's disease to see how it affects brain inflammation and the health of brain cells, and it's for anyone interested in understanding more about what might influence the progression of Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10524611 on NIH RePORTER |
What this research studies
This research focuses on the role of the BIN1 protein, which is linked to Alzheimer's disease, particularly in how it influences inflammation in the brain. Researchers will study how BIN1 affects microglial cells, which are crucial for brain health and immune response. By examining the genetic variations associated with BIN1, the project aims to understand its impact on inflammatory signaling pathways that may contribute to Alzheimer's disease progression. The approach includes both laboratory experiments and analysis of genetic data to uncover the mechanisms involved.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those with genetic factors related to BIN1.
Not a fit: Patients with Alzheimer's disease not associated with BIN1 genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting inflammation in Alzheimer's disease, potentially slowing its progression.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglial proteins in neuroinflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Thinakaran, Gopal — University of South Florida
- Study coordinator: Thinakaran, Gopal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.