Investigating how a specific protein affects immune cells in heart disease
Official title: TRPM7-mediated macrophage signaling in atherosclerosis
Funded at University of Connecticut Sch of Med/dnt · NIH-11071116 · Data updated 2026-11-12
This study is looking at how a protein called TRPM7 affects immune cells that help control inflammation and fat levels in the arteries, with the hope that understanding this could lead to new treatments for atherosclerosis, a condition where plaque builds up in the arteries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $45,122 |
| NIH project number | 1F31HL178225-01 |
| Project ID | NIH-11071116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis, including those with cardiovascular disease or related risk factors.
✕Less likely to help
Patients who do not have atherosclerosis or related cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called TRPM7 in the development of atherosclerosis, a condition characterized by plaque buildup in the arteries. It examines how TRPM7 influences the behavior of macrophages, which are immune cells that help manage inflammation and lipid levels in the arteries. By using a model that mimics atherosclerosis, the research aims to uncover how manipulating TRPM7 can alter macrophage function and potentially reduce the progression of this disease. Patients may benefit from insights that could lead to new treatments targeting this protein.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in cardiovascular diseases, suggesting potential for success in this approach.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Li, Cindy Xintong — University of Connecticut Sch of Med/dnt
- Study coordinator: Li, Cindy Xintong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.