Investigating how a specific protein affects HIV interactions in the body
Official title: Role of PCIF1 in Regulating Host-HIV interactions
Funded at University of California, San Diego · NIH-11113394 · Data updated 2026-11-12
This study is looking at how a protein called PCIF1 affects the way HIV interacts with our cells, which could help us find new ways to treat HIV and improve our understanding of the virus for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 24, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $502,861 |
| NIH project number | 1R56AI187411-01 |
| Project ID | NIH-11113394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who are not interested in experimental treatments may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called PCIF1 in regulating how HIV interacts with host cells. By examining the modifications of RNA, particularly the m6A and m6Am types, the study aims to uncover how these changes influence gene expression and the body's response to HIV. The researchers will explore the molecular mechanisms that allow HIV to replicate and persist in the body, which could lead to new insights into treatment strategies. Patients may benefit from a deeper understanding of HIV biology and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or even a functional cure for HIV/AIDS.
How similar studies have gone: Other research has shown promising results in understanding RNA modifications and their roles in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Rana, Tariq M — University of California, San Diego
- Study coordinator: Rana, Tariq M
Related research
Other NIH-funded projects on the same topics.
-
Improved MRI guidance for pediatric heart catheterization using autonomous multi-beat image synthesis
Aiming to make MRI-guided pediatric heart catheterizations safer and more reliable by using smart, multi-beat data fusion to produce clearer real-time MRI images.
-
Adapting a combination approach to reduce heavy drinking and boost HIV care and prevention among young men
A pilot project tests a proven program that helps young men cut down on heavy drinking and improves HIV treatment and prevention outcomes.
-
How specific anti-NMDAR1 antibodies in the blood may affect memory and brain protection
This research is exploring whether natural or abnormal anti-NMDAR1 antibodies in the blood influence memory, behavior, and brain protection in humans.
-
Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth
This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.
-
Pharmacometrics Core at UC San Diego
A pharmacometrics core is funded to support researchers in analyzing drug data to improve how medicines work for patients.
-
Milk Analytics Core for Precision Dairy Research
A core facility at UC San Diego will provide specialized milk analysis services to support research on dairy biology and human health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.