Investigating how a specific protein affects heart function in heart failure
Fast myosin binding protein-C and cardiac contractility in heart failure
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11253202
This study is looking at a special protein in the heart called fast myosin binding protein-C to see how it affects heart muscle contractions, especially in people with heart failure, with the hope of finding new ways to improve heart function and treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11253202 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of fast myosin binding protein-C (fMyBP-C) in heart failure, a condition that significantly impacts adults. The study examines how fMyBP-C regulates heart muscle contraction and its effects on cardiac function, particularly during heart failure. By using transgenic mouse models, researchers will explore the molecular mechanisms that govern fMyBP-C's influence on heart muscle cells, aiming to uncover new insights into cardiac contractility. This could lead to better understanding and potential treatments for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure or related cardiac dysfunction.
Not a fit: Patients with heart conditions unrelated to the mechanisms being studied, such as congenital heart defects, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving heart function in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding cardiac proteins and their roles in heart function, suggesting that this approach could yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SADAYAPPAN, SAKTHIVEL — UNIVERSITY OF ARIZONA
- Study coordinator: SADAYAPPAN, SAKTHIVEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.