Investigating how a specific protein affects heart function in heart failure
Official title: Fast myosin binding protein-C and cardiac contractility in heart failure
Funded at University of Arizona · NIH-11253202 · Data updated 2026-11-12
This study is looking at a special protein in the heart called fast myosin binding protein-C to see how it affects heart muscle contractions, especially in people with heart failure, with the hope of finding new ways to improve heart function and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | January 3, 2025 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $386,875 |
| NIH project number | 7R01HL105826-12 |
| Project ID | NIH-11253202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing heart failure or related cardiac dysfunction.
✕Less likely to help
Patients with heart conditions unrelated to the mechanisms being studied, such as congenital heart defects, may not benefit from this research.
What this research studies
This research focuses on understanding the role of fast myosin binding protein-C (fMyBP-C) in heart failure, a condition that significantly impacts adults. The study examines how fMyBP-C regulates heart muscle contraction and its effects on cardiac function, particularly during heart failure. By using transgenic mouse models, researchers will explore the molecular mechanisms that govern fMyBP-C's influence on heart muscle cells, aiming to uncover new insights into cardiac contractility. This could lead to better understanding and potential treatments for heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving heart function in patients with heart failure.
How similar studies have gone: Previous research has shown promising results in understanding cardiac proteins and their roles in heart function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Sadayappan, Sakthivel — University of Arizona
- Study coordinator: Sadayappan, Sakthivel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.