Investigating how a specific protein affects heart function and treatment for heart failure
STK25 phosphorylates PRKAR1A to regulate PKA signaling
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10895537
This study is looking at how a protein called STK25 affects another protein important for heart cell function, with the hope of finding new ways to treat heart failure and help people who are living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10895537 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called STK25 in regulating another protein, PRKAR1A, which is crucial for heart cell function. By studying how these proteins interact, the research aims to identify new therapeutic targets for heart failure, a condition that currently lacks effective treatments. The approach involves using human stem cell-derived heart cells and animal models to explore the effects of manipulating these proteins on heart health. The ultimate goal is to develop better therapies that can improve outcomes for patients with heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from heart failure or those at high risk for developing this condition.
Not a fit: Patients with heart conditions unrelated to heart failure may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Other research has shown promising results in targeting similar pathways for improving heart function, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FINE, BARRY M. — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: FINE, BARRY M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.