Investigating how a specific protein affects heart function and treatment for heart failure
Official title: STK25 phosphorylates PRKAR1A to regulate PKA signaling
Funded at Columbia University Health Sciences · NIH-10895537 · Data updated 2026-11-12
This study is looking at how a protein called STK25 affects another protein important for heart cell function, with the hope of finding new ways to treat heart failure and help people who are living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $552,991 |
| NIH project number | 5R01HL166387-02 |
| Project ID | NIH-10895537 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from heart failure or those at high risk for developing this condition.
✕Less likely to help
Patients with heart conditions unrelated to heart failure may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called STK25 in regulating another protein, PRKAR1A, which is crucial for heart cell function. By studying how these proteins interact, the research aims to identify new therapeutic targets for heart failure, a condition that currently lacks effective treatments. The approach involves using human stem cell-derived heart cells and animal models to explore the effects of manipulating these proteins on heart health. The ultimate goal is to develop better therapies that can improve outcomes for patients with heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve heart function and outcomes for patients with heart failure.
How similar studies have gone: Other research has shown promising results in targeting similar pathways for improving heart function, indicating that this approach has potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Fine, Barry M. — Columbia University Health Sciences
- Study coordinator: Fine, Barry M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.