Investigating how a specific protein affects heart disease protection
Role of PKC Epsilon in Atheroprotection
This study is looking at a protein called PKC Epsilon to see how it helps the body deal with heart disease by reducing inflammation and plaque buildup in arteries, which could lead to new ways to prevent heart problems, especially in older adults.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-11096137 on NIH RePORTER |
What this research studies
This research explores the role of a protein called PKC Epsilon in the body's response to heart disease, particularly focusing on how it influences inflammation and the resolution of that inflammation. By studying genetically modified mice, the researchers aim to understand how this protein can help reduce plaque buildup in arteries, which is a key factor in cardiovascular disease. The approach involves examining the signaling pathways that link the uptake of harmful substances to the body's ability to heal and resolve inflammation. This could lead to new insights into preventing heart disease in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults at risk for cardiovascular disease, especially those with high cholesterol levels.
Not a fit: Patients who are not at risk for cardiovascular disease or who have other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent cardiovascular disease, particularly in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in cardiovascular disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Albany, United States
- Albany Medical College — Albany, United States (Active)
Researchers
- Principal investigator: Lennartz, Michelle R — Albany Medical College
- Study coordinator: Lennartz, Michelle R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.