Investigating how a specific protein affects heart disease protection
Official title: Role of PKC Epsilon in Atheroprotection
Funded at Albany Medical College · NIH-11096137 · Data updated 2026-11-12
This study is looking at a protein called PKC Epsilon to see how it helps the body deal with heart disease by reducing inflammation and plaque buildup in arteries, which could lead to new ways to prevent heart problems, especially in older adults.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $238,620 |
| NIH project number | 1R21AI185827-01A1 |
| Project ID | NIH-11096137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults at risk for cardiovascular disease, especially those with high cholesterol levels.
✕Less likely to help
Patients who are not at risk for cardiovascular disease or who have other unrelated health conditions may not benefit from this research.
What this research studies
This research explores the role of a protein called PKC Epsilon in the body's response to heart disease, particularly focusing on how it influences inflammation and the resolution of that inflammation. By studying genetically modified mice, the researchers aim to understand how this protein can help reduce plaque buildup in arteries, which is a key factor in cardiovascular disease. The approach involves examining the signaling pathways that link the uptake of harmful substances to the body's ability to heal and resolve inflammation. This could lead to new insights into preventing heart disease in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent cardiovascular disease, particularly in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in cardiovascular disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Lennartz, Michelle R — Albany Medical College
- Study coordinator: Lennartz, Michelle R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.