Investigating how a specific protein affects glioblastoma growth and the tumor environment.
The oncogenic functions of Neuropilin-1 in the glioblastoma tumor microenvironment
This study is looking at how certain immune cells in the brain can help glioblastoma tumors grow and develop new blood vessels, with the goal of finding ways to change these immune cells so they can help fight the tumor instead of helping it thrive.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10872145 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, the most common brain tumor in adults, which has a poor survival rate despite current treatments. It examines the role of immune cells in the tumor microenvironment, particularly how they contribute to tumor growth and blood vessel formation through a protein called Neuropilin-1. The study aims to understand the interactions between these immune cells and tumor cells, especially in low-oxygen conditions, to find ways to alter their behavior to fight the tumor instead of supporting it.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against glioblastoma, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting immune cell interactions in tumors, suggesting that this approach may lead to significant advancements in glioblastoma treatment.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Radin, Daniel — State University New York Stony Brook
- Study coordinator: Radin, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.