Investigating how a specific protein affects gene expression in heart cells.
Official title: Post-Transcriptional Regulation of Gene Expression by Ribosome-Binding Protein 1
Funded at University of Arizona · NIH-11087711 · Data updated 2026-11-12
This study is looking at how a protein called RRBP1 helps control the way heart muscle cells make important proteins, especially after heart injuries, to find new ways to help the heart heal and work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | May 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $740,143 |
| NIH project number | 5R01HL170223-02 |
| Project ID | NIH-11087711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cardiac diseases or those who have experienced myocardial infarction.
✕Less likely to help
Patients with non-cardiac conditions or those without any history of heart disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of ribosome-binding protein 1 (RRBP1) in regulating gene expression at the post-transcriptional level in cardiac myocytes, which are the muscle cells of the heart. The study aims to explore how RRBP1 interacts with RNA in the endoplasmic reticulum (ER) to influence the production of secretory proteins that are crucial for heart function. By examining the effects of RRBP1 on cardiac health, particularly after events like myocardial infarction, the research seeks to uncover new mechanisms that could improve heart recovery and function. Patients may benefit from insights gained about how to enhance cardiac repair processes through targeted protein regulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving heart function and recovery after cardiac injuries.
How similar studies have gone: While the specific focus on RRBP1 is novel, previous studies have shown success in understanding post-transcriptional regulation in other contexts, suggesting potential for impactful findings.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Doroudgar, Shirin — University of Arizona
- Study coordinator: Doroudgar, Shirin
Related research
Other NIH-funded projects on the same topics.
-
Retinal signals in early diabetes and how they affect vision
This grant looks at how diabetes changes the signals in the retina that control vision, with a focus on inner retinal cells and how these changes may lead to vision problems.
-
Mining safety training that connects research to practice for Western miners
A patient-facing overview of a U.S. mining safety program that partners universities and mining operators to improve training, safety practices, and outcomes for mine workers in the Western United States.
-
Developing small molecules to treat TDP-43 related brain diseases
A potential new drug candidate (XL20) for diseases like Alzheimer’s and other dementias linked to TDP-43 protein problems is being developed and refined for people who live with these conditions.
-
Mobile platform using AI to screen for oral cancer in low-resource communities
A low-cost, AI-powered mobile tool helps frontline healthcare workers screen for oral cancer and triage patients in communities with limited access to specialists.
-
A new optical method to image skin cancers using synthetic waves
A small grant is funding the development and testing of tissue-mimicking skin phantoms to improve non-invasive imaging of skin cancers.
-
MRI-guided precision care for infants with cleft palate
We’re exploring how MRI can help tailor early care for babies with cleft palate to support better speech outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.