Investigating how a specific protein affects facial development
Srsf3-mediated alternative RNA splicing in craniofacial development
This study is looking at how a protein called Srsf3 affects the development of the face, especially in understanding why some babies are born with facial clefts, and it hopes to find new ways to help those with craniofacial birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10783812 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Srsf3 protein in craniofacial development, particularly how it influences alternative RNA splicing. By studying mouse models, the research aims to uncover the molecular mechanisms that lead to facial clefting when Srsf3 is absent. The approach involves examining the signaling pathways activated by the platelet-derived growth factor receptor alpha (PDGFRa) and how these pathways affect gene expression related to facial structure. Patients with craniofacial birth defects may benefit from insights gained through this research, which could lead to improved prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with craniofacial birth defects or those with a family history of such conditions.
Not a fit: Patients with craniofacial conditions unrelated to genetic or developmental factors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for craniofacial birth defects.
How similar studies have performed: Previous research has shown success in understanding the role of signaling pathways in craniofacial development, making this approach promising.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Fantauzzo, Katherine Ann — University of Colorado Denver
- Study coordinator: Fantauzzo, Katherine Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.