Investigating how a specific protein affects eye health and diseases
Characterization of the role of MIF on retinal health and disease
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10887601
This study is looking at how a protein called MIF affects eye health, especially in people with diabetes or sickle cell disease, and aims to find new ways to protect vision by reducing inflammation in the retina.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10887601 on ClinicalTrials.gov |
What this research studies
This research explores the role of macrophage migration inhibitory factor (MIF) in retinal health, particularly its involvement in inflammatory processes that lead to vision loss in conditions like diabetic retinopathy and sickle cell retinopathy. By targeting MIF, the study aims to develop new therapies that could prevent retinal damage and improve outcomes for patients with these diseases. The approach includes both pharmacological and genetic methods to inhibit MIF and assess its effects on neuronal survival in models of retinal injury. The findings could lead to innovative treatments that address the underlying causes of retinal inflammation and damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from retinal diseases such as diabetic retinopathy, sickle cell retinopathy, or other ischemic retinal conditions.
Not a fit: Patients with retinal diseases not related to inflammation or ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce vision loss in patients with retinal diseases.
How similar studies have performed: Previous research has shown promise in targeting inflammatory pathways for retinal diseases, suggesting that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CEBULLA, COLLEEN MARIE — OHIO STATE UNIVERSITY
- Study coordinator: CEBULLA, COLLEEN MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.