Investigating how a specific protein affects colon cancer growth and spread
Role of PTPRT in colon cancer progression and metastasis
This study is looking at a protein called PTPRT and how changes in it might affect the growth and spread of colon cancer, using special mice to help find new ways to understand and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10893342 on NIH RePORTER |
What this research studies
This research focuses on the role of the protein PTPRT in colon cancer, particularly how its mutations may influence cancer progression and metastasis. The study aims to understand the enzymatic activity of PTPRT, which has been previously thought to be inactive, and how it regulates important signaling pathways in cancer cells. By using genetically modified mice and advanced bioinformatics, the researchers will explore how changes in PTPRT affect tumor development and spread in colorectal cancer. This could lead to new insights into the mechanisms of cancer and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with mutations in the PTPRT gene.
Not a fit: Patients with non-colorectal cancers or those without PTPRT mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colon cancer by targeting the PTPRT protein.
How similar studies have performed: Previous research has indicated that targeting similar signaling pathways in cancer has shown promise, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wang, Zhenghe — Case Western Reserve University
- Study coordinator: Wang, Zhenghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.