Investigating how a specific protein affects cocaine-related behavior and brain changes
Role of Gadd45b in Cocaine-driven Epigenetic and Behavioral Dynamics
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11056696
This study is looking at how a protein called Gadd45b affects the brain and behavior when someone uses cocaine, with the goal of finding new ways to help people struggling with cocaine addiction by understanding the changes that happen in the brain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11056696 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called Gadd45b in how cocaine affects the brain and behavior. It aims to explore how cocaine triggers changes in brain cells that can lead to addiction and maladaptive behaviors. By examining the molecular and epigenetic changes in specific brain regions, the study seeks to uncover potential mechanisms that could be targeted for new treatments for cocaine addiction. Patients may be involved in understanding how their experiences with cocaine relate to these biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have a history of cocaine use or addiction.
Not a fit: Patients who do not use cocaine or have not experienced substance abuse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for individuals struggling with cocaine addiction.
How similar studies have performed: While the specific role of Gadd45b in cocaine addiction is not well-established, similar research has shown promise in understanding the molecular basis of addiction and behavioral changes.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAY, JEREMY J — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: DAY, JEREMY J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder