Investigating how a specific protein affects breast cancer cell behavior
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
This study is looking at how changes in a protein related to breast cancer might affect how the cancer cells behave, with the hope of finding better ways to treat aggressive forms of the disease that don't respond well to usual treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10991028 on NIH RePORTER |
What this research studies
This research focuses on understanding how alterations in a protein called manganese superoxide dismutase (MnSOD) influence the behavior of estrogen receptor-positive breast cancer cells. By examining how changes in the acetylation of this protein affect cell metabolism and the accumulation of reactive oxygen species, the study aims to uncover mechanisms that lead to therapy resistance and tumor progression. Patients may benefit from insights gained about how to better target and treat aggressive forms of breast cancer that are resistant to standard therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with estrogen receptor-positive breast cancer, particularly those who have experienced recurrence or resistance to endocrine therapy.
Not a fit: Patients with non-estrogen receptor-positive breast cancers or those who have not undergone endocrine therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with therapy-resistant breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial dysfunction in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Gius, David — University of Texas Hlth Science Center
- Study coordinator: Gius, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.