Investigating how a specific protein affects brain health and survival in Alzheimer's disease.
Official title: Molecular Mechanisms of Tubulin Polymerization Promoting Protein in Mitochondrial Function and Neuronal Survival
Funded at University of Texas Hlth Science Center · NIH-10981129 · Data updated 2026-11-12
This study is looking at how a specific protein called TPPP affects brain health in Alzheimer's and similar diseases using fruit flies, with the hope of finding new ways to help people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $397,839 |
| NIH project number | 1R01NS134867-01A1 |
| Project ID | NIH-10981129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those under 21 years old.
✕Less likely to help
Patients with neurodegenerative diseases other than Alzheimer's or related dementias may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of Tubulin Polymerization Promoting Proteins (TPPP) in the context of Alzheimer's disease and related dementias. Using a novel fruit fly model, researchers will explore how mutations in TPPP lead to neurodegeneration and mitochondrial dysfunction, which are key features of these diseases. The study aims to uncover the molecular mechanisms behind these processes, potentially leading to new therapeutic targets. Patients may benefit from insights gained about the underlying causes of their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar proteins in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Banerjee, Swati — University of Texas Hlth Science Center
- Study coordinator: Banerjee, Swati
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.