Investigating how a specific protein affects brain aging and Alzheimer's disease
Official title: Role of oligodendrocyte-derived IL-33 in brain aging and Alzheimer's disease
Funded at Temple Univ of the Commonwealth · NIH-11092778 · Data updated 2026-11-12
This study is looking at a protein called IL-33 in the aging brain to see how it affects the brain's ability to get rid of harmful substances linked to Alzheimer's disease, with the hope of finding new ways to help people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $721,936 |
| NIH project number | 5R01AG078565-03 |
| Project ID | NIH-11092778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients who are younger than one year old or those without any cognitive decline may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of IL-33, a protein produced by oligodendrocytes, in the aging brain and its implications for Alzheimer's disease. By studying how IL-33 levels change with age and how they influence the brain's ability to clear harmful substances like amyloid plaques, the research aims to uncover potential therapeutic strategies. The approach involves analyzing brain cells and their responses to age-related changes, which could lead to new insights into cognitive decline and neurodegenerative diseases. Patients may benefit from findings that could inform future treatments for Alzheimer's and other age-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of neuroinflammation and specific proteins in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Kang, Shin H — Temple Univ of the Commonwealth
- Study coordinator: Kang, Shin H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.