Investigating how a specific protein affects bone loss as we age
Regulation of age-related bone loss by PKIgamma
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10840269
This study is looking at how a protein called PKIgamma affects bone health as we age, especially for older adults with osteoporosis, to see if targeting this protein can make current treatments work better and help strengthen bones and prevent fractures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10840269 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the protein PKIgamma influences age-related bone loss, particularly in older adults. The study aims to explore the potential of targeting this protein to enhance the effectiveness of existing osteoporosis treatments, such as intermittent Parathyroid Hormone-like drugs. By using genetically modified mice, researchers will assess how the absence of PKIgamma affects bone health and healing over time. The ultimate goal is to identify new therapeutic strategies that could improve bone density and reduce fracture risk in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing age-related bone loss or are at risk for osteoporosis.
Not a fit: Patients who are not experiencing age-related bone loss or who are younger than 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for osteoporosis, potentially improving bone health and reducing fracture rates in older adults.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for enhancing bone health, suggesting that this approach may hold significant potential.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREENFIELD, EDWARD M. — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: GREENFIELD, EDWARD M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.