Investigating how a specific protein affects blood vessel malformations.
Official title: The Role of c-ABL in Mediating TIE2 Signaling and Formation of Venous Malformation
Funded at University of Cincinnati · NIH-10997562 · Data updated 2026-11-12
This study is looking at how a protein called c-ABL affects a signaling pathway related to abnormal blood vessel growths known as venous malformations, and it aims to find out if blocking c-ABL can help reduce these growths to improve treatment options for people dealing with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 15, 2024 |
| Project end | September 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $46,386 |
| NIH project number | 1F31HL176101-01 |
| Project ID | NIH-10997562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with venous malformations, particularly those with mutations in the TIE2 receptor.
✕Less likely to help
Patients without venous malformations or those whose conditions are unrelated to TIE2 signaling may not benefit from this research.
What this research studies
This research focuses on understanding the role of the c-ABL protein in the signaling pathway of TIE2, which is linked to the formation of venous malformations (VMs). These are abnormal blood vessel growths that can cause pain and complications. The researchers will use advanced 3D modeling techniques and in vivo models to explore how c-ABL influences TIE2 activation and whether inhibiting c-ABL can reduce the formation of these malformations. This approach aims to uncover new therapeutic targets for treating VMs more effectively.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from venous malformations.
How similar studies have gone: While the specific approach of targeting c-ABL in relation to TIE2 is novel, similar studies have shown promise in understanding vascular malformations and signaling pathways.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Bischoff, Lindsay — University of Cincinnati
- Study coordinator: Bischoff, Lindsay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.