Investigating how a specific protein affects blood vessel health in brain aneurysms
Official title: Role of p62-Mediated Endothelial FA-Phagy in Intracranial Aneurysms
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10757731 · Data updated 2026-11-12
This study is looking at a protein called p62 to see how it affects the health of blood vessels in the brain, especially in relation to dangerous bulges known as intracranial aneurysms, with the hope of finding new ways to prevent or treat them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $195,000 |
| NIH project number | 5R21NS130570-02 |
| Project ID | NIH-10757731 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing intracranial aneurysms or those with a history of vascular issues.
✕Less likely to help
Patients who do not have any vascular conditions or a family history of aneurysms may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called p62 in the health of blood vessels, particularly in relation to intracranial aneurysms (IA). Intracranial aneurysms are dangerous bulges in blood vessels in the brain that can lead to severe complications if they rupture. The researchers will explore how p62 affects the stability of blood vessels and contributes to the development of aneurysms. By examining the mechanisms of how p62 interacts with other cellular components, the study aims to identify potential new treatment targets for preventing or treating IAs.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the development or rupture of intracranial aneurysms, significantly improving patient outcomes.
How similar studies have gone: While the specific approach of targeting p62-mediated autophagy in relation to intracranial aneurysms is novel, similar studies have shown promise in understanding vascular health and disease.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Rui, Yanning — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Rui, Yanning
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.