Investigating how a specific protein affects blood vessel growth in lung cancer
ST6GalNAc-I/MUC5AC promoting angiogenesis in lung adenocarcinoma
This study is looking at how a protein called ST6GalNAc-I affects the growth of blood vessels in lung adenocarcinoma, a type of lung cancer, to find new ways to improve treatment for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10670397 on NIH RePORTER |
What this research studies
This research focuses on non-small cell lung cancer, particularly lung adenocarcinoma, which is known for its aggressive nature and poor prognosis. The study aims to understand how the protein ST6GalNAc-I influences the growth of blood vessels in tumors, which is crucial for tumor development and metastasis. By examining the role of this protein in the tumor microenvironment, researchers hope to uncover new mechanisms that could lead to improved treatment strategies. The approach involves analyzing the effects of manipulating this protein on cancer cell behavior and blood vessel formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung adenocarcinoma or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of lung cancer or those without lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve survival rates for patients with lung adenocarcinoma.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Lakshmanan, Imayavaramban — University of Nebraska Medical Center
- Study coordinator: Lakshmanan, Imayavaramban
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.