Investigating how a specific protein affects blood stem cells and cancer development
The role of Abelson interactor 1 (Abi-1) in hematopoietic stem cell self-renewal and malignant transformation
This study is looking at a protein called Abi-1 to see how it affects blood stem cells, which are important for making blood, especially in people with blood cancers like myeloproliferative neoplasms, to help find better treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10651698 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called Abelson interactor 1 (Abi-1) in the behavior of hematopoietic stem cells, which are crucial for blood formation. The study aims to uncover how Abi-1 influences the self-renewal and differentiation of these stem cells, particularly in the context of myeloproliferative neoplasms (MPNs), a group of blood cancers. By examining the signaling pathways involved, the researchers hope to identify new therapeutic targets that could lead to more effective treatments for patients with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myeloproliferative neoplasms, particularly those with primary myelofibrosis.
Not a fit: Patients with other types of blood disorders or those not diagnosed with myeloproliferative neoplasms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively target and eliminate the cancerous stem cells responsible for myeloproliferative neoplasms.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in blood cancers, suggesting that this approach could be effective.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Dubielecka-Szczerba, Patrycja Marta — Rhode Island Hospital
- Study coordinator: Dubielecka-Szczerba, Patrycja Marta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.