Investigating how a specific protein affects blood pressure regulation
Official title: The Role of CIC-6 in Vascular Control of Blood Pressure
Funded at University of South Florida · NIH-10894175 · Data updated 2026-11-12
This study is looking at how a protein called ClC-6 helps control blood pressure by affecting the cells in your blood vessels, and it could help us understand more about high blood pressure and how to manage it better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL153686-05 |
| Project ID | NIH-10894175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for hypertension or have been diagnosed with high blood pressure.
✕Less likely to help
Patients who do not have hypertension or related cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the ClC-6 protein in controlling blood pressure by studying its effects on vascular smooth muscle cells. Researchers will explore how ClC-6 influences calcium storage and signaling within these cells, which is crucial for maintaining healthy blood pressure levels. By using advanced techniques like electrophysiology and calcium imaging, the study aims to uncover the molecular mechanisms behind blood pressure regulation. This could lead to new insights into hypertension and its associated risks.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension, potentially reducing the risk of serious cardiovascular events.
How similar studies have gone: Previous studies have shown promising results in understanding the genetic factors influencing hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Klemens, Christine Anne — University of South Florida
- Study coordinator: Klemens, Christine Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.