Investigating how a specific protein affects blood flow and brain health in Alzheimer's disease
The roles of pericyte-derived laminin in neurovascular function and neurodegeneration
This study is looking at a protein in the brain that helps keep blood vessels healthy and how it might affect Alzheimer's disease, with the hope of finding new ways to help people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10892759 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called pericytic laminin in the brain's blood vessels and its impact on Alzheimer's disease. The study will explore how this protein influences the integrity of the blood-brain barrier and cerebral blood flow, which are crucial for brain health. Using advanced imaging techniques, researchers will assess how the loss of this protein affects brain function and neuronal survival. The findings could lead to new therapeutic strategies targeting these mechanisms to improve outcomes for patients with Alzheimer's and related dementias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other types of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain function and improve the quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting components of the neurovascular unit for treating neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yao, Yao — University of South Florida
- Study coordinator: Yao, Yao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.