Investigating how a specific protein affects aging in fat tissue.
Official title: Role of Histone Deacetylase 9 (HDAC9) in adipose tissue aging: mitochondrial function, oxidative stress and senescence
Funded at Augusta University · NIH-10904832 · Data updated 2026-11-12
This study is looking at how a protein called HDAC9 affects the aging of fat cells, which could help us understand health problems related to aging, like obesity and heart disease, and might lead to new treatments for these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | August 15, 2022 |
| Project end | August 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AG074640-03 |
| Project ID | NIH-10904832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include older adults experiencing age-related metabolic issues or conditions associated with adipose tissue dysfunction.
✕Less likely to help
Patients with acute or non-age-related metabolic disorders may not receive direct benefits from this research.
What this research studies
This research explores the role of histone deacetylase 9 (HDAC9) in the aging of adipose tissue, which is crucial for understanding how fat cells contribute to age-related health issues. The study will utilize mouse models to examine how increased levels of HDAC9 may lead to mitochondrial dysfunction and oxidative stress in fat cells. By analyzing the effects of HDAC9 on fat cell aging, the research aims to uncover potential mechanisms that could be targeted for therapeutic interventions. Patients may benefit from insights gained about fat tissue aging and its implications for conditions like obesity and cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases linked to fat tissue dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the role of histone deacetylases in cellular aging, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Goo, Brandee — Augusta University
- Study coordinator: Goo, Brandee
Related research
Other NIH-funded projects on the same topics.
-
Oxidative stress and Nlrp3 inflammasome activation in eye lens aging
This grant looks at how aging and oxidative stress drive inflammation in the eye lens, which could help prevent age-related eye diseases.
-
How aging and cell stress damage salivary glands in Sjögren’s
Researchers are testing whether getting older and increased oxidative (cell) stress make salivary glands more likely to be damaged in Sjögren’s, using mouse models that mimic the disease.
-
How aging and oxidative stress affect salivary gland disease in Sjögren’s Syndrome
This study is looking at how getting older and stress in the body might affect the salivary glands in people with Sjögren’s Syndrome, with the hope of finding better ways to treat and manage the condition.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.