Investigating how a specific protein affects aging in fat tissue.
Role of Histone Deacetylase 9 (HDAC9) in adipose tissue aging: mitochondrial function, oxidative stress and senescence
['FUNDING_FELLOWSHIP'] · AUGUSTA UNIVERSITY · NIH-10904832
This study is looking at how a protein called HDAC9 affects the aging of fat cells, which could help us understand health problems related to aging, like obesity and heart disease, and might lead to new treatments for these issues.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-10904832 on ClinicalTrials.gov |
What this research studies
This research explores the role of histone deacetylase 9 (HDAC9) in the aging of adipose tissue, which is crucial for understanding how fat cells contribute to age-related health issues. The study will utilize mouse models to examine how increased levels of HDAC9 may lead to mitochondrial dysfunction and oxidative stress in fat cells. By analyzing the effects of HDAC9 on fat cell aging, the research aims to uncover potential mechanisms that could be targeted for therapeutic interventions. Patients may benefit from insights gained about fat tissue aging and its implications for conditions like obesity and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include older adults experiencing age-related metabolic issues or conditions associated with adipose tissue dysfunction.
Not a fit: Patients with acute or non-age-related metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases linked to fat tissue dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the role of histone deacetylases in cellular aging, suggesting that this approach may yield valuable insights.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOO, BRANDEE — AUGUSTA UNIVERSITY
- Study coordinator: GOO, BRANDEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.