Investigating how a specific protein affects aging and obesity
A role for DUSP5 in aging and obesity
This study is looking at how getting older and being overweight can cause inflammation in the body, and how a protein called DUSP5 might be involved in this process, especially for older adults who are at risk for diabetes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project ID | NIH-10625471 on NIH RePORTER |
What this research studies
This research explores the connection between aging, obesity, and inflammation, focusing on how a protein called DUSP5 may play a role in these processes. It examines how chronic inflammation in older adults, particularly those who are obese, can lead to insulin resistance and diabetes. The study aims to understand the mechanisms by which certain proteins are activated or deactivated in response to inflammation in adipose tissue, which is crucial for maintaining metabolic health. By identifying these molecular pathways, the research seeks to uncover potential therapeutic targets to prevent or treat age-related metabolic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those who are obese and at risk for insulin resistance and diabetes.
Not a fit: Patients who are not elderly or do not have obesity-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent diabetes and other metabolic diseases in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in aging and obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
Reno, United States
- University of Nevada Reno — Reno, United States (Active)
Researchers
- Principal investigator: Ferguson, Bradley S — University of Nevada Reno
- Study coordinator: Ferguson, Bradley S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.