Investigating how a specific proteasome affects aging and metabolism
Official title: The 11S-associated immunoproteasome in mitochondrial function and metabolic disorders
Funded at University of Minnesota · NIH-11085072 · Data updated 2026-11-12
This study is looking at how a special part of our immune system, called the immunoproteasome, affects aging, inflammation, and metabolism, and it's for people interested in understanding how these processes work in older adults and those with chronic liver issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $407,884 |
| NIH project number | 5R01DK135286-03 |
| Project ID | NIH-11085072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults and individuals with metabolic disorders or chronic inflammatory conditions.
✕Less likely to help
Patients who are young and healthy, without any metabolic or inflammatory conditions, may not benefit from this research.
What this research studies
This research focuses on understanding the role of the immunoproteasome in regulating tissue aging, inflammation, and metabolic disorders. It examines how the immunoproteasome, which differs from the standard proteasome, is activated during inflammation and its impact on protein degradation. By studying its effects in aged mice and rats, as well as in human liver biopsies from patients with chronic liver conditions, the research aims to uncover how this proteasome influences metabolic changes and inflammation in the body.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders and age-related diseases by targeting the immunoproteasome.
How similar studies have gone: Previous research has shown promising results in understanding the role of the immunoproteasome in inflammation and metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Kim, Do-Hyung — University of Minnesota
- Study coordinator: Kim, Do-Hyung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.