Investigating how a specific protease affects biofilm formation and infections caused by Enterococcus faecalis.
Role of the enterococcal site 2 protease in biofilm formation, adaptation, and host-pathogen interactions
['FUNDING_R01'] · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · NIH-10550124
This study is looking at how a protein called Eep helps the bacteria Enterococcus faecalis form protective layers that make it harder for our immune system and antibiotics to fight off infections, with the goal of finding new ways to treat and prevent these tough infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HENRY M. JACKSON FDN FOR THE ADV MIL/MED (nih funded) |
| Locations | 1 site (BETHESDA, UNITED STATES) |
| Trial ID | NIH-10550124 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific protease, known as Eep, in the formation of biofilms by Enterococcus faecalis, a bacterium that causes serious healthcare-associated infections. The study aims to uncover how Eep influences the bacterium's ability to adapt to the immune system and develop resistance to antibiotics. By examining the biochemical activities of Eep, the research seeks to identify new strategies for treating and preventing infections caused by this pathogen, which is known for its resilience against conventional treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with healthcare-associated infections caused by Enterococcus faecalis, particularly those who have not responded to standard antibiotic treatments.
Not a fit: Patients with infections caused by bacteria other than Enterococcus faecalis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Previous research has shown promise in targeting similar proteases in other bacterial pathogens, indicating potential for success in this approach.
Where this research is happening
BETHESDA, UNITED STATES
- HENRY M. JACKSON FDN FOR THE ADV MIL/MED — BETHESDA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANK, KRISTI L — HENRY M. JACKSON FDN FOR THE ADV MIL/MED
- Study coordinator: FRANK, KRISTI L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.