Investigating how a specific pathway in the kidneys affects salt-sensitive high blood pressure
Renal acid ceramidase-S1P pathway in salt-sensitive hypertension
This study is looking at how a substance called sphingosine-1-phosphate affects kidney function, especially in people with high blood pressure and those who eat a lot of salt, to find new ways to help manage salt-sensitive hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10943173 on NIH RePORTER |
What this research studies
This research explores the role of sphingosine-1-phosphate (S1P) in the kidneys, particularly how it influences sodium excretion and blood pressure regulation. The study focuses on the enzyme acid ceramidase, which is involved in producing S1P, and examines its behavior under conditions of high salt intake and hypertension. By understanding these mechanisms, the research aims to uncover new insights into managing salt-sensitive hypertension, potentially leading to novel treatment strategies. Patients may be involved in studies assessing their blood pressure responses and sodium handling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with salt-sensitive hypertension or related kidney conditions.
Not a fit: Patients with hypertension that is not influenced by salt intake may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing high blood pressure, particularly in patients sensitive to salt intake.
How similar studies have performed: Previous research has shown promising results in understanding the role of S1P in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Li, Ningjun — Virginia Commonwealth University
- Study coordinator: Li, Ningjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.