Investigating how a specific pathway in the kidneys affects salt-sensitive high blood pressure
Official title: Renal acid ceramidase-S1P pathway in salt-sensitive hypertension
Funded at Virginia Commonwealth University · NIH-10943173 · Data updated 2026-11-12
This study is looking at how a substance called sphingosine-1-phosphate affects kidney function, especially in people with high blood pressure and those who eat a lot of salt, to find new ways to help manage salt-sensitive hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | August 7, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $467,473 |
| NIH project number | 1R01DK140219-01 |
| Project ID | NIH-10943173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with salt-sensitive hypertension or related kidney conditions.
✕Less likely to help
Patients with hypertension that is not influenced by salt intake may not benefit from this research.
What this research studies
This research explores the role of sphingosine-1-phosphate (S1P) in the kidneys, particularly how it influences sodium excretion and blood pressure regulation. The study focuses on the enzyme acid ceramidase, which is involved in producing S1P, and examines its behavior under conditions of high salt intake and hypertension. By understanding these mechanisms, the research aims to uncover new insights into managing salt-sensitive hypertension, potentially leading to novel treatment strategies. Patients may be involved in studies assessing their blood pressure responses and sodium handling.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing high blood pressure, particularly in patients sensitive to salt intake.
How similar studies have gone: Previous research has shown promising results in understanding the role of S1P in kidney function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Li, Ningjun — Virginia Commonwealth University
- Study coordinator: Li, Ningjun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.