Investigating how a specific pathway affects cancer cell growth
The kynurenine-AHR pathway in biomass production
This study is looking at how a specific pathway in the body affects the growth of colon cancer cells, with the hope of finding new ways to slow down or stop cancer from growing, and it's for anyone interested in better treatments for colon cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10977335 on NIH RePORTER |
What this research studies
This research focuses on understanding how the kynurenine-AHR pathway influences the growth and protein synthesis of colon cancer cells. By studying the role of the aryl hydrocarbon receptor (AHR) and its interaction with kynurenine, a byproduct of tryptophan, the research aims to uncover mechanisms that drive tumor growth. The approach includes genetic silencing techniques in human and mouse colon cancer models to assess how these factors contribute to cancer cell proliferation. The ultimate goal is to identify potential therapeutic targets that could limit cancer biomass production.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colon cancer who may benefit from novel therapeutic strategies.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with colon cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically inhibit cancer cell growth by targeting the kynurenine-AHR pathway.
How similar studies have performed: Previous studies have shown promising results in targeting metabolic pathways in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Conacci-Sorrell, Maralice — Ut Southwestern Medical Center
- Study coordinator: Conacci-Sorrell, Maralice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.