Investigating how a specific pathway affects cancer cell growth
The kynurenine-AHR pathway in biomass production
This study is looking at how a specific pathway in the body affects the growth of colon cancer cells, and it's for anyone interested in finding new ways to slow down cancer by understanding how certain proteins are made in these cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10792646 on NIH RePORTER |
What this research studies
This research focuses on understanding how the kynurenine-AHR pathway influences the growth of colon cancer cells. By examining the role of the aryl hydrocarbon receptor (AHR) and its interaction with kynurenine, a byproduct of tryptophan, the study aims to uncover mechanisms that drive protein synthesis in cancer cells. The researchers will use genetic techniques to silence specific genes in human and mouse colon cancer cells to assess how this pathway contributes to tumor growth. The ultimate goal is to identify new strategies to limit cancer cell proliferation by targeting this pathway.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colon cancer who are seeking innovative treatment options.
Not a fit: Patients with non-cancerous conditions or those with cancers unrelated to the colon may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically inhibit the growth of colon cancer cells.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Conacci-Sorrell, Maralice — Ut Southwestern Medical Center
- Study coordinator: Conacci-Sorrell, Maralice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.