Investigating how a specific pathway affects blood stem cell function
The role of GSK3/PPAR-/mitophagy pathway in regulating hematopoia
['FUNDING_R01'] · CORIELL INSTITUTE FOR MEDICAL RESEARCH · NIH-11006281
This study is looking at how a specific pathway in our cells can help improve the health and function of blood stem cells, which are important for making blood, with the hope of finding better treatments for blood disorders like leukemia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORIELL INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (CAMDEN, UNITED STATES) |
| Trial ID | NIH-11006281 on ClinicalTrials.gov |
What this research studies
This research explores the role of the GSK3/PPAR-δ/mitophagy pathway in maintaining and regulating hematopoietic stem cells (HSCs), which are crucial for producing blood cells. The study aims to understand how manipulating this pathway can enhance the self-renewal and functionality of HSCs, potentially improving outcomes for patients with blood disorders. Researchers will examine the interactions between GSK3, PPAR-δ, and mitophagy to uncover mechanisms that could lead to better therapies for conditions like acute myeloid leukemia. By using advanced techniques, the study will assess how these molecular processes can be targeted to improve HSC performance in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or other related hematologic malignancies who may benefit from stem cell transplantation.
Not a fit: Patients with non-hematologic conditions or those who do not have a need for stem cell therapies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with acute myeloid leukemia and other blood disorders by enhancing the effectiveness of hematopoietic stem cell therapies.
How similar studies have performed: Previous research has shown promising results in manipulating similar pathways to enhance stem cell function, indicating potential for success in this approach.
Where this research is happening
CAMDEN, UNITED STATES
- CORIELL INSTITUTE FOR MEDICAL RESEARCH — CAMDEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, JIAN — CORIELL INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: HUANG, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.