Investigating how a specific pathway affects blood stem cell function
Official title: The role of GSK3/PPAR-/mitophagy pathway in regulating hematopoia
Funded at Coriell Institute for Medical Research · NIH-11006281 · Data updated 2026-11-12
This study is looking at how a specific pathway in our cells can help improve the health and function of blood stem cells, which are important for making blood, with the hope of finding better treatments for blood disorders like leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $448,906 |
| NIH project number | 5R01HL157118-04 |
| Project ID | NIH-11006281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or other related hematologic malignancies who may benefit from stem cell transplantation.
✕Less likely to help
Patients with non-hematologic conditions or those who do not have a need for stem cell therapies may not receive any benefit from this research.
What this research studies
This research explores the role of the GSK3/PPAR-δ/mitophagy pathway in maintaining and regulating hematopoietic stem cells (HSCs), which are crucial for producing blood cells. The study aims to understand how manipulating this pathway can enhance the self-renewal and functionality of HSCs, potentially improving outcomes for patients with blood disorders. Researchers will examine the interactions between GSK3, PPAR-δ, and mitophagy to uncover mechanisms that could lead to better therapies for conditions like acute myeloid leukemia. By using advanced techniques, the study will assess how these molecular processes can be targeted to improve HSC performance in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with acute myeloid leukemia and other blood disorders by enhancing the effectiveness of hematopoietic stem cell therapies.
How similar studies have gone: Previous research has shown promising results in manipulating similar pathways to enhance stem cell function, indicating potential for success in this approach.
Where this research is happening
-
Coriell Institute for Medical Research
Camden, United States Active
Researchers
- Principal investigator: Huang, Jian — Coriell Institute for Medical Research
- Study coordinator: Huang, Jian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.