Investigating how a specific mutation affects blood cell signaling in chronic blood disorders.
Official title: JAK2V617F transactivation of JAK1 mediates constitutive activation of IL-10R signaling
Funded at University of California-Irvine · NIH-10998487 · Data updated 2026-11-12
This study is looking at a specific gene mutation in people with Myeloproliferative Neoplasms (MPNs) to see how it affects blood cell behavior, with the hope of finding new ways to treat the condition and help patients feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,539 |
| NIH project number | 1F31HL176174-01 |
| Project ID | NIH-10998487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Myeloproliferative Neoplasms who have the JAK2V617F mutation.
✕Less likely to help
Patients without the JAK2V617F mutation or those with other types of blood disorders may not benefit from this research.
What this research studies
This research focuses on Myeloproliferative Neoplasms (MPNs), a group of chronic blood disorders characterized by the JAK2V617F mutation. The study aims to understand how this mutation leads to abnormal signaling in blood cells, particularly through the IL-10 receptor pathway, which is typically impaired in MPN patients. By using a specialized murine pro B-cell model, the researchers will analyze the mechanisms that allow these mutant cells to thrive despite the dysfunctional signaling. The goal is to identify new therapeutic targets that could help combat disease progression and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms driving MPN, potentially improving survival and quality of life for patients.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in blood disorders, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Wadley, William Lucas Paredes — University of California-Irvine
- Study coordinator: Wadley, William Lucas Paredes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.