Investigating how a specific muscle protein affects the neuromuscular system
The effect of muscle-specific anchoring protein on the biology of the Neuromuscular system
This study is looking at how a special protein helps keep nerve and muscle connections strong, which is important for movement, and it hopes to find new ways to help people with neuromuscular diseases where these connections aren't working well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10609859 on NIH RePORTER |
What this research studies
This research explores the role of a muscle-specific anchoring protein in maintaining the stability of receptors at the neuromuscular junction, which is crucial for effective communication between nerves and muscles. The study involves manipulating the levels of this protein in mice to observe its effects on the development and maintenance of neuromuscular synapses. By understanding these mechanisms, the research aims to shed light on neuromuscular diseases where receptor stability is compromised, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neuromuscular diseases that affect receptor stability, particularly those over 21 years old.
Not a fit: Patients with conditions unrelated to neuromuscular junction stability or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neuromuscular diseases by enhancing our understanding of receptor stability.
How similar studies have performed: Previous research has shown promising results in understanding neuromuscular junction stability, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Akaaboune, Mohammed — University of Michigan at Ann Arbor
- Study coordinator: Akaaboune, Mohammed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.