Investigating how a specific muscle molecule affects blood vessel repair in diabetes
Official title: MyomiR-499, Exosomes and Endothelial and Endothelial Progenitor Cells dysfunction in Diabetes
Funded at Temple Univ of the Commonwealth · NIH-11051878 · Data updated 2026-11-12
This study is looking at how diabetes affects the cells that help repair blood vessels and whether a specific molecule called miR-499 can make this repair harder, with the goal of finding new ways to help people with diabetes who have serious leg problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $555,099 |
| NIH project number | 5R01HL169405-02 |
| Project ID | NIH-11051878 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are diabetic patients experiencing issues with blood flow and limb repair, particularly those at risk for critical limb ischemia.
✕Less likely to help
Patients without diabetes or those not experiencing vascular complications may not benefit from this research.
What this research studies
This research focuses on understanding how diabetes impacts the function of endothelial and endothelial progenitor cells, which are crucial for repairing blood vessels. The study aims to explore the role of a molecule called miR-499, which is found in muscle tissue, and how it may impair the ability of these cells to repair damaged limbs in diabetic patients. By examining the delivery of miR-499 through exosomes, the researchers hope to uncover new therapeutic strategies to enhance blood vessel repair in individuals suffering from critical limb ischemia due to diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel repair in diabetic patients, potentially reducing complications like critical limb ischemia.
How similar studies have gone: Previous research has shown promising results in enhancing endothelial cell function in diabetes, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Kishore, Raj — Temple Univ of the Commonwealth
- Study coordinator: Kishore, Raj
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.