Investigating how a specific molecule affects the anti-cancer effects of sulindac in colorectal cancer.
Official title: MiR-17 mediates sulindac anti-metastatic activity in human colorectal cancer
Funded at Charlie Norwood VA Medical Center · NIH-10980418 · Data updated 2026-11-12
This study is looking at how a molecule called MiR-17 affects how well the drug sulindac works for treating advanced colorectal cancer, with the hope of finding better and safer treatment options for veterans facing this illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Charlie Norwood VA Medical Center NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 30, 2022 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 7I01BX005094-03 |
| Project ID | NIH-10980418 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with advanced colorectal cancer who are seeking new treatment options.
✕Less likely to help
Patients with early-stage colorectal cancer or those not affiliated with the Veterans Affairs system may not benefit from this research.
What this research studies
This research focuses on understanding how the molecule MiR-17 influences the effectiveness of sulindac, a nonsteroidal anti-inflammatory drug, in treating colorectal cancer (CRC). The study aims to explore the mechanisms by which sulindac can reduce tumor growth and metastasis in patients with advanced CRC. By analyzing patient samples and utilizing animal models, the research seeks to identify potential biomarkers that could predict treatment response. The ultimate goal is to develop more effective and safer therapeutic options for veterans suffering from this disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for colorectal cancer, potentially increasing survival rates and quality of life for patients.
How similar studies have gone: Previous studies have shown promising results with the use of sulindac in reducing cancer risk, indicating that this approach has potential based on existing evidence.
Where this research is happening
-
Charlie Norwood VA Medical Center
Augusta, United States Active
Researchers
- Principal investigator: Xi, Yaguang — Charlie Norwood VA Medical Center
- Study coordinator: Xi, Yaguang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.