Investigating how a specific modification in brain cells affects brain function.
Astrocytic Heparan Sulfate 6-O-Sulfation in Brain Function
['FUNDING_R15'] · NEW YORK INST OF TECHNOLOGY · NIH-10578904
This study is looking at how a specific change in brain chemistry might affect brain function and contribute to conditions like Alzheimer's disease, using mice to help find new ways to treat these disorders that could eventually help patients.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK INST OF TECHNOLOGY (nih funded) |
| Locations | 1 site (OLD WESTBURY, UNITED STATES) |
| Trial ID | NIH-10578904 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of heparan sulfate 6-O-sulfation in brain function and its connection to various brain disorders, particularly Alzheimer's disease. By using mouse models, the researchers aim to uncover how disruptions in this modification can impact behavior and brain activity. The study will explore the molecular mechanisms involved, which could lead to new therapeutic strategies for treating brain disorders. Patients may benefit from insights gained that could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients with brain disorders not related to heparan sulfate 6-O-sulfation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients suffering from Alzheimer's disease and other related brain disorders.
How similar studies have performed: While the specific approach of investigating HS 6-O-sulfation in adult brain function is novel, related research has shown promise in understanding the role of astrocytes in brain disorders.
Where this research is happening
OLD WESTBURY, UNITED STATES
- NEW YORK INST OF TECHNOLOGY — OLD WESTBURY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, JERRY YINGTAO — NEW YORK INST OF TECHNOLOGY
- Study coordinator: ZHAO, JERRY YINGTAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome