Investigating how a specific modification in brain cells affects brain function.
Official title: Astrocytic Heparan Sulfate 6-O-Sulfation in Brain Function
Funded at New York Inst of Technology · NIH-10578904 · Data updated 2026-11-12
This study is looking at how a specific change in brain chemistry might affect brain function and contribute to conditions like Alzheimer's disease, using mice to help find new ways to treat these disorders that could eventually help patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Inst of Technology NIH-funded |
| Lab location | 1 site (Old Westbury, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $428,400 |
| NIH project number | 1R15NS130456-01 |
| Project ID | NIH-10578904 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients with brain disorders not related to heparan sulfate 6-O-sulfation may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of heparan sulfate 6-O-sulfation in brain function and its connection to various brain disorders, particularly Alzheimer's disease. By using mouse models, the researchers aim to uncover how disruptions in this modification can impact behavior and brain activity. The study will explore the molecular mechanisms involved, which could lead to new therapeutic strategies for treating brain disorders. Patients may benefit from insights gained that could inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients suffering from Alzheimer's disease and other related brain disorders.
How similar studies have gone: While the specific approach of investigating HS 6-O-sulfation in adult brain function is novel, related research has shown promise in understanding the role of astrocytes in brain disorders.
Where this research is happening
-
New York Inst of Technology
Old Westbury, United States Active
Researchers
- Principal investigator: Zhao, Jerry Yingtao — New York Inst of Technology
- Study coordinator: Zhao, Jerry Yingtao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.