Investigating how a specific microRNA helps the immune system tolerate pregnancy.
Official title: Placenta-specific miR-519c-mediated induction of immune tolerance in human placenta
Funded at NYU Long Island School of Medicine · NIH-10795000 · Data updated 2026-11-12
This study is looking at how a tiny molecule called miR-519c helps a pregnant woman's immune system protect her baby while still fighting off infections, with the goal of finding ways to prevent problems during pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | April 2, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $321,233 |
| NIH project number | 5R01HD098258-06 |
| Project ID | NIH-10795000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals who may be at risk for complications due to immune system issues.
✕Less likely to help
Patients who are not pregnant or those with pre-existing severe immune disorders may not benefit from this research.
What this research studies
This research explores the role of a specific microRNA, miR-519c, in promoting immune tolerance during pregnancy. It aims to understand how the maternal immune system adapts to protect the fetus from rejection while still defending against infections. By studying the mechanisms of immune tolerance in the context of repeated inflammatory stimuli, the research seeks to uncover how this balance can prevent complications in pregnancies. The approach involves analyzing the effects of miR-519c on immune responses and its potential to mitigate inflammation-related issues during pregnancy.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing pregnancy complications related to immune responses.
How similar studies have gone: While the specific focus on miR-519c in pregnancy is novel, there is existing evidence that similar approaches to understanding immune tolerance have shown promise in other contexts.
Where this research is happening
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NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Hanna, Nazeeh N — NYU Long Island School of Medicine
- Study coordinator: Hanna, Nazeeh N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.