Investigating how a specific microRNA affects immune cells in fat tissue during obesity
MiR-150 regulated adiose tissue B cells in obesity
This study is looking at how certain immune cells in fat tissue, called B cells, behave during obesity and how a tiny molecule, miR-150, affects them, with the hope of finding new ways to help improve health for people dealing with obesity-related issues like inflammation and insulin resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10793567 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of adipose tissue B cells, which are immune cells found in fat tissue, particularly during obesity. The study aims to identify how a microRNA called miR-150 regulates these B cells and their function, which may contribute to inflammation and insulin resistance associated with obesity. By exploring the molecular mechanisms behind B cell activation and interaction within adipose tissue, the research seeks to uncover potential therapeutic targets to improve metabolic health in obese individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and may be experiencing metabolic issues such as insulin resistance.
Not a fit: Patients who are not obese or do not have metabolic syndromes related to obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help reduce inflammation and improve insulin sensitivity in obese patients.
How similar studies have performed: While the role of B cells in adipose tissue is a relatively new area of investigation, preliminary studies suggest that targeting these cells may have therapeutic potential, indicating a promising avenue for further exploration.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Zhou, Beiyan — University of Connecticut Sch of Med/dnt
- Study coordinator: Zhou, Beiyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.