Investigating how a specific microRNA affects fat tissue and insulin resistance
MiR-409-3p Regulates Angiogensis, Brown Fat Adiposity and Insulin Resistance
['FUNDING_R01'] · TUFTS MEDICAL CENTER · NIH-10840468
This study is looking at how a tiny molecule called microRNA-409-3p affects the growth of blood vessels in fat tissues and how this might relate to insulin resistance, which is important for people with diabetes. By studying samples from both mice and humans, the researchers hope to find new ways to improve fat tissue function and help manage diabetes better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10840468 on ClinicalTrials.gov |
What this research studies
This research explores the role of microRNA-409-3p in regulating blood vessel formation in fat tissues and its impact on insulin resistance. By examining samples from both mice and humans, the study aims to understand how changes in this microRNA can influence the growth and movement of cells in brown and white adipose tissues. The researchers will utilize advanced techniques to manipulate the levels of this microRNA and observe the resulting effects on fat tissue function and metabolism, which could lead to new insights into diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with insulin resistance or diabetes, particularly those with obesity-related conditions.
Not a fit: Patients without insulin resistance or those who do not have any metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving insulin sensitivity and managing diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in metabolic diseases, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ICLI, BASAK — TUFTS MEDICAL CENTER
- Study coordinator: ICLI, BASAK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.