Investigating how a specific lipid helps the liver heal after acetaminophen overdose
Official title: The role of phosphatidic acid in liver regeneration after acetaminophen overdose
Funded at Univ of Arkansas for Med Scis · NIH-11053510 · Data updated 2026-11-12
This study is looking at how a fat called phosphatidic acid helps the liver heal after an overdose of acetaminophen, which can cause serious liver damage, and it aims to find new treatments to help people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $328,034 |
| NIH project number | 5R01DK135752-02 |
| Project ID | NIH-11053510 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute liver injury or failure due to acetaminophen overdose.
✕Less likely to help
Patients with liver injury from causes other than acetaminophen overdose may not benefit from this research.
What this research studies
This research focuses on understanding the role of phosphatidic acid, a type of lipid, in liver regeneration following an acetaminophen overdose, which is a leading cause of acute liver failure. The study aims to explore how phosphatidic acid influences liver cell growth and repair by inhibiting a protein that normally prevents liver cells from proliferating. By using mouse models, the researchers will investigate the mechanisms behind this process to identify potential new treatments for liver injury. This could lead to improved therapies for patients suffering from severe liver damage due to acetaminophen.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance liver regeneration and reduce the need for liver transplants in patients with acetaminophen-induced liver injury.
How similar studies have gone: Previous research has shown promising results in understanding liver regeneration mechanisms, but the specific role of phosphatidic acid in this context is relatively novel.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Mcgill, Mitchell Ryan — Univ of Arkansas for Med Scis
- Study coordinator: Mcgill, Mitchell Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.