Investigating how a specific lipid affects heart rhythm in diabetes
Official title: Leukotriene B4 Regulation in Heart
Funded at University of Utah · NIH-10936974 · Data updated 2026-11-12
This study is looking at how a substance called leukotriene B4 might cause dangerous heart rhythms in people with type 2 diabetes, with the hope of finding new ways to prevent sudden heart problems using existing medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $643,426 |
| NIH project number | 1R01HL174450-01 |
| Project ID | NIH-10936974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may be at risk for cardiac arrhythmias.
✕Less likely to help
Patients without type 2 diabetes or those who do not have a history of cardiac issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of leukotriene B4 (LTB4), a lipid mediator, in causing dangerous heart rhythms in patients with type 2 diabetes. The study aims to identify how elevated levels of LTB4 contribute to the risk of sudden cardiac death due to arrhythmias. By using various models, including mouse studies, the researchers will explore the cellular mechanisms that lead to these heart rhythm disturbances. The ultimate goal is to validate LTB4 as a target for treatment, potentially using existing FDA-approved drugs that inhibit LTB4.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of fatal heart rhythms in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in targeting LTB4 for cardiovascular benefits, indicating that this approach may be effective.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Aromolaran, Ademuyiwa — University of Utah
- Study coordinator: Aromolaran, Ademuyiwa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.