Investigating how a specific lipid affects heart inflammation and failure in obese patients
Official title: Lysophosphatidic acid mediates cardiac inflammation and heart failure with preserved ejection fraction
Funded at Veterans Health Administration · NIH-10975915 · Data updated 2026-11-12
This study is looking at how a substance called lysophosphatidic acid (LPA) affects heart inflammation and heart failure in people who are obese, with the goal of finding new ways to help improve their heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01CX002684-02 |
| Project ID | NIH-10975915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals who are at risk for or diagnosed with heart failure with preserved ejection fraction (HFpEF).
✕Less likely to help
Patients who are not obese or do not have heart failure with preserved ejection fraction may not benefit from this research.
What this research studies
This research focuses on understanding the role of lysophosphatidic acid (LPA) in cardiac inflammation and heart failure with preserved ejection fraction (HFpEF), particularly in obese individuals. The study aims to explore the mechanisms by which obesity-induced inflammation contributes to HFpEF, a condition that significantly impacts the health of many patients. By examining the levels of LPA and its effects on cardiac signaling and remodeling, the research seeks to identify potential therapeutic targets for improving patient outcomes. The approach includes analyzing plasma levels of LPA and related biomarkers in both human patients and animal models to establish a clearer understanding of the underlying processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target cardiac inflammation in obese patients, potentially improving their heart health and quality of life.
How similar studies have gone: While there have been studies on inflammation and heart failure, the specific focus on lysophosphatidic acid in the context of HFpEF in obese patients is relatively novel and has not been extensively tested.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Abdel-Latif, Ahmed — Veterans Health Administration
- Study coordinator: Abdel-Latif, Ahmed
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.