Investigating how a specific ion channel affects pain
The role of a lysosomal mechano-sensitive ion channel in pain
This study is looking at how a specific channel in our cells, called Tmem63A, affects chronic pain, especially pain that comes from nerve injuries, to help find new ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10580905 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a lysosomal ion channel, Tmem63A, in chronic pain, particularly neuropathic pain resulting from peripheral nerve injury. The researchers will explore how this ion channel mediates currents in specific neurons and contributes to pain sensations. By using advanced techniques such as single-cell PCR and immunocytochemistry, they aim to determine the mechanisms behind the ion channel's function and its potential as a target for new pain treatments. Patients may benefit from insights gained about pain mechanisms that could lead to better therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic neuropathic pain, particularly those with a history of peripheral nerve injury.
Not a fit: Patients with acute pain conditions or those not experiencing neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain, improving the quality of life for many patients.
How similar studies have performed: Previous research has shown promise in targeting ion channels for pain management, suggesting that this approach could yield significant insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Fehrenbacher, Jill C — Indiana University Indianapolis
- Study coordinator: Fehrenbacher, Jill C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.