Investigating how a specific ion channel affects blood flow regulation
TRPV1 and the regulation of arterial tone
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-10839356
This study is looking at how tiny blood vessels help control blood flow and pressure during exercise and in people with heart disease or diabetes, focusing on a special channel that helps these vessels change size quickly; it's for anyone interested in understanding how these processes work, especially as we age or deal with health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10839356 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how small blood vessels, known as arterioles, regulate blood flow and blood pressure, particularly during physical activity and in conditions like heart disease and diabetes. The study will explore the role of a specific ion channel, TRPV1, which is believed to help these vessels adjust their size quickly in response to changes in blood flow. By using specialized mice and various functional tests, researchers aim to uncover the mechanisms behind this regulation and how it may be affected by aging and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with heart disease, diabetes, or those experiencing age-related vascular issues.
Not a fit: Patients without cardiovascular issues or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions that impair blood flow, improving health outcomes for patients with heart disease, diabetes, and other related conditions.
How similar studies have performed: Previous research has shown promising results in understanding blood flow regulation through similar mechanisms, suggesting potential for success in this investigation.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AHERN, GERARD P — GEORGETOWN UNIVERSITY
- Study coordinator: AHERN, GERARD P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.